Trofosfamide

Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.^1,2 It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.³ Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.¹ It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.²

WARNING This product is not for human or veterinary use.

1. Devlin, R.G., Schwartz, N.L., Baronowsky, P.E., et al. Inhibition of cellular immune reactions by cyclophosphamide analogues ifosfamide and trofosfamide. I. Mixed lymphocyte reaction. Proc. Soc. Exp. Biol. Med. 145(2), 389-391 (1974).

2. Harrison, E.F., and Fuquay, M.E. Immunosuppressive properties of cyclophosphamide analogues. Proc. Soc. Exp. Biol. Med. 139(3), 957-963 (1972).

3. Wild, D. Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test. Mutat. Res. 56(3), 319-327 (1978).